British Indian medic hails exciting cancer blood test results

British Indian medic hails exciting cancer blood test results
Courtesy: TEK IMAGE/SCIENCE PHOTO LIBRARY | Science Photo Library Via Getty Images
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“These exciting results will inform our development of an optimised classifier for use in symptomatic patients with a suspicion of cancer,” said Sir Harpal Kumar, President of GRAIL Europe, with reference to the findings of a new study that could make cancer diagnosis quicker in future.

The Galleri test – developed by US healthcare company GRAIL – covers more than 50 types of cancer and showed promise after correctly revealing two out of every three cancers in people who had visited their general practitioner (GP) with suspected symptoms in England or Wales. It also correctly identified the original site of cancer in 85 per cent of those cases in what has been described as the first large-scale evaluation of a multi-cancer early detection (MCED) test in individuals who presented to their GP for diagnostic follow-up for suspected cancer.

“GRAIL’s earlier PATHFINDER study previously demonstrated that adding GRAIL’s MCED testing to standard of care screening more than doubled the number of cancers detected compared with standard screening alone in adults with no symptoms or suspicion of cancer. Now, the SYMPLIFY data confirm the potential benefit of methylation-based MCED blood tests as a diagnostic aid for use in the symptomatic patient population,” explained Sir Harpal.

The findings of the SYMPLIFY study, backed by the National Health Service (NHS), was presented at the American Society of Oncology conference in Chicago last week. It enrolled 6,238 patients, aged 18 and older, who were referred for urgent imaging, endoscopy or other diagnostic modalities to investigate symptoms suspicious for possible gynaecological, lung, lower GI or upper GI cancer, or who had presented with non-specific symptoms.

Brian D. Nicholson, Associate Professor at Oxford University’s Nuffield Department of Primary Care Health Sciences and co-lead investigator of the study, said: “New tools that can both expedite cancer diagnosis and potentially avoid invasive and costly investigations are needed to more accurately triage patients who present with non-specific cancer symptoms.

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“The high overall specificity, positive predictive value, and accuracy of the cancer signal detected and cancer signal origin prediction that was reported across cancer types in the SYMPLIFY study indicate that a positive MCED test could be used to confirm that symptomatic patients should be evaluated for cancer before pursuing other diagnoses.”

Participants provided a blood sample, from which DNA was isolated and tested. Most patients diagnosed with cancer in England and Wales first see a primary care physician for the investigation of symptoms suggestive of cancer. The most commonly reported symptoms leading to referral were unexpected weight loss (24.1 per cent), change in bowel habit (22.0 per cent), post-menopausal bleeding (16.0 per cent), rectal bleeding (15.7 per cent), abdominal pain (14.5 per cent), pain (10.6 per cent), difficulty swallowing (8.8 per cent) and anaemia (7.1 per cent).

NHS national director for cancer Professor Peter Johnson added: “This study is the first step in testing a new way to identify cancer as quickly as possible, being pioneered by the NHS – earlier detection of cancer is vital and this test could help us to catch more cancers at an earlier stage and help save thousands of lives.”

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The University of Oxford sponsored the SYMPLIFY study and was responsible for data collection, analysis and interpretation. The study was funded by GRAIL, with support from NHS England, NHS Wales, the National Institute for Health and Care Research (NIHR) and NIHR Oxford Biomedical Research Centre.

*Info: SYMPLIFY

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